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239173

FABRICATION OF TOPICAL BACLOFEN LOADED EMULGEL: CHARACTERIZATION, OPTIMIZATION USING 23 FULL FACTORIAL DESIGN AND IN VIVO ANTI-INFLAMMATORY ACTIVITY

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Last updated: 04 Jan 2025

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Abstract

Baclofen is a GABA-B receptors agonist and possesses anti-inflammatory properties. It has many gastrointestinal side effects and narrow therapeutic index. Thus, the objective of this study was to produce emulgel for the topical delivery of baclofen so as to evade its side effects. Emulgel containing 1% baclofen were fabricated, evaluated and optimized applying full factorial design (23). Liquid paraffin concentration, cremophor RH 40 concentration, and penetration enhancers type was selected as independent variables in the current study to determine the influence of them on the percentage release of baclofen after 30 minutes. The anti-inflammatory activity of the optimal baclofen emulgel was assessed employing the carragenan-induced rat paw edema method. The formulation E5 was established to fulfill the maximum requisite of an optimum formulation with desirability value of 0.982. The mean percentage inhibition value of E5 after 1 hour of application was significantly higher than Baclofen® tablet, baclofen hydrogel and Voltaren® emulgel. The % relative bioavailability of E5 was 108.9%, 99.8% and 138.6% relative to Baclofen® tablet, Voltaren® emulgel and baclofen hydrogel respectively. Therefore, baclofen emulgel can be utilized as an effective anti-inflammatory for topical drug delivery.

DOI

10.21608/bfsa.2022.239173

Keywords

Baclofen, Emulgel, Topical drug delivery, Rat paw edema

Authors

First Name

Kareem

Last Name

Rashwan

MiddleName

Omar

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, 6th of October City, Egypt

Email

moongair@live.com

City

-

Orcid

-

First Name

Ghada

Last Name

Abdelbary

MiddleName

Ali

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Nabarawi

MiddleName

Ahmed

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

nabrwima@hotmail.com

City

-

Orcid

-

First Name

Nabaweya

Last Name

El Gawad

MiddleName

Abdelaziz Abd

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, 6th of October City, Egypt/ Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Sara

Last Name

Soliman

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, October 6 University, 6th of October City, Egypt

Email

sara.soliman@o6u.edu.eg

City

-

Orcid

0000-0003-3143-5894

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-12-27

Publish Date

2022-06-01

Page Start

41

Page End

52

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 41-52.pdf

PDF . 1.1MB

Link

https://bpsa.journals.ekb.eg/article_239173.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239173

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FABRICATION OF TOPICAL BACLOFEN LOADED EMULGEL: CHARACTERIZATION, OPTIMIZATION USING 23 FULL FACTORIAL DESIGN AND IN VIVO ANTI-INFLAMMATORY ACTIVITY

Details

Type

Article

Created At

22 Jan 2023