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239156

THE EFFECT OF TABLET GEOMETRY ON TRAMADOL HYDROCHLORIDE RELEASE FROM MATRIX SYSTEMS

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Last updated: 25 Dec 2024

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Abstract

The objective of this study was to explore the effect of geometry and tablet design on release pattern of tramadol hydrochloride as a model of freely soluble drug from matrix systems. Hydrophilic and hydrophobic matrices were prepared by direct compression method using HPMC with two different molecular weight and Kollidon® SR as a release-retarding agent respectively at drug: polymer ratio (1:5) for each excipient, in distinct strengths and geometries (i.e. shape, size and dimensions) at parallel and differing surface area to volume ratios. It was found that tramadol release from manufactured tablets is similar when the surface area to volume ratio is equal, regardless of the type of matrix former, drug strength, tablet design. Per contra, the tablet with smaller surface area to volume values had the slower release rate among the same shape. Thus, tablet geometry supplies additional versatility for these systems, making formulators to achieve the desired release characteristics for their drug of option.

DOI

10.21608/bfsa.2022.239156

Keywords

matrix systems, Tablet geometry, Surface area to volume ratio, Tramadol hydrochloride

Authors

First Name

Hadi

Last Name

Shammout

MiddleName

-

Affiliation

Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Lattakia city, Syria

Email

hadishammout2@gmail.com

City

-

Orcid

-

First Name

Wassim

Last Name

Abdelwahed

MiddleName

-

Affiliation

Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Aleppo University, Aleppo city, syria

Email

wassimabed@yahoo.fr

City

-

Orcid

-

First Name

Wehad

Last Name

Ibrahim

MiddleName

-

Affiliation

Deptartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Lattakia city, Syria.

Email

wehad.ibrahim@tishreen.edu.sy

City

-

Orcid

-

Volume

45

Article Issue

1

Related Issue

34403

Issue Date

2022-06-01

Receive Date

2021-06-27

Publish Date

2022-06-01

Page Start

1

Page End

10

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 45_Issue 1_Pages 1-10.pdf

PDF . 733.2kB

Link

https://bpsa.journals.ekb.eg/article_239156.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=239156

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE EFFECT OF TABLET GEOMETRY ON TRAMADOL HYDROCHLORIDE RELEASE FROM MATRIX SYSTEMS

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Type

Article

Created At

22 Jan 2023