Beta
ManageSearchChatDiscover
207178

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The etiology of inflammatory and autoimmune diseases is complex and not yet fully
understood. Their pathogenesis includes mechanisms in which both innate and adaptive
immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells
expressing an invariant TCRα chain (Vα7.2-Jα33 in human and Vα19-Jα33 in mice) and
recognize the conserved MHC-I-related molecule MR1, which presents bacterial metabolites
derived from the synthesis of vitamin B. Although most of the studies support a hazardous role
of MAIT cells in tissue inflammation and destruction, few studies suggest a protective role.
MAIT cells have tissue homing properties with the production of inflammatory cytokines,
signifying that they may play an essential role in autoimmune and inflammatory diseases. In the
current study, we clarified the present knowledge on MAIT cells in systemic lupus
erythematosus.

DOI

10.21608/bfsa.2021.207178

Authors

First Name

rehab

Last Name

mekkawy

MiddleName

-

Affiliation

Forensic Medicine Authority, Ministry of Justice, Egypt.

Email

rehab_abdelhakim2015@yahoo.com.sg

City

-

Orcid

0000-0002-6183-6392

First Name

Omnia

Last Name

El-badawy

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt.

Email

-

City

-

Orcid

-

First Name

Helal

Last Name

F. Hetta

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt , Department of internal Medicine, College of Medicine, University of Cincinati, Cincinati, OH 45267-0595, USA.

Email

-

City

-

Orcid

-

First Name

Doaa

Last Name

K. Abd El-hafez

MiddleName

-

Affiliation

Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

M. Hassanein

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

Email

-

City

-

Orcid

-

Volume

44

Article Issue

2

Related Issue

29160

Issue Date

2021-12-01

Receive Date

2021-04-17

Publish Date

2021-12-01

Page Start

511

Page End

524

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 2_Pages 511-524.pdf

PDF . 737.0kB

Link

https://bpsa.journals.ekb.eg/article_207178.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=207178

Order

19

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS

Details

Type

Article

Created At

22 Jan 2023