Osteoporosis is an important problem in women's health, one of the consequences of
which is bone fracture. This clinical trial was performed in 2015 on 99 (33 patients per group)
postmenopausal women referred to the bone mineral densitometry center. The first group
received one Agnugol tablet (contains 3.2-4.8 mg dry extract of Vitex agnus castus, the second
group received three Salvigol tablets (each contains 100 mg Salvia officinal is dry extract daily
and the third group three placebo tablets per day for 3 months. Calcium, phosphorus and
vitamin D levels were compared before and after the intervention. Results of paired t-test
showed that the mean of calcium and phosphorus level increased after intervention in the Vitex
agnus and salvia officinalis extract groups, but there was no significant difference in the control
group. LSD follow-up test was used, showing that the mean difference of calcium and
phosphorus score between the Vitex agnus, S. officinalis extract and control groups was
significant in pairwise comparisons. However, the difference between the score of phosphorus
level in Vitex agnus and S. officinalis extract groups was not significant after the intervention.
After intervention, the mean of vitamin D increased by 2.4 units in the Vitex agnus group
compared to before the intervention. However, there was no statistically significant difference
between the Vitex agnus and control groups after the intervention compared to before it. The
Vitex agnus was effective in increasing calcium, phosphorus and vitamin D level, while S.
officinalis extract was effective in increasing the level of calcium and phosphorus.