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174139

CYTOTOXIC EFFECT OF DEFINE CONCENTRATION OF YARROW (ACHILLEA MILLEFOLIUM) EXTRACT USED IN IRANIAN TRADITIONAL MEDICINE ON AGS HUMAN GASTRIC CANCER CELL-LINE

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Last updated: 04 Jan 2025

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Abstract

Gastric cancer is one of the main cancer-related death causes in the world threatening almost 12 million human lives by 2020. Achillea millefolium L. (yarrow) with domestic Iranian name of Bumadaran, has been as a curative plant for several medical conditions for a long time. Its antimicrobial and wound healing effects have been reported and in this study, we aimed to survey the in-vitro cytotoxic and anti-cancer effects of this plant. After taxonomically identification of Achillea millefolium L., its hydroalcoholic extract was extracted and the AGS gastric cancer and L-929 normal fibroblastic cell-lines with treated by the different concentrations of extract in 3 time periods (24, 48, and 72 hrs). MTT assay was performed for the evaluation of cytotoxic effects. The 24 hrs treatment did not affect cell survival, notably, while the concentrations of 64 and 16 µg/ml were determined as IC50 concentrations at 48 and 72 hrs incubation times respectively. The 72 hrs incubation time with 16 µg/ml showed the best effectiveness on cancerous cell-line while being safe for normal cell-line. The long-term treatment of AGS cancer cell-line by low concentrations of yarrow extract could be useful for the cytotoxicity upon this type of cancerous cells.

DOI

10.21608/bfsa.2021.174139

Authors

First Name

Mohammad

Last Name

Hashemi

MiddleName

Mostakhdem

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

Email

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City

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Orcid

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First Name

Nahid

Last Name

Poursharifi

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

Email

nahidpoursharifi@yahoo.com

City

-

Orcid

-

First Name

Fariba

Last Name

Kokabi

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

Email

faribakokabi@gmail.com

City

-

Orcid

-

First Name

Jale

Last Name

Yuzugulen

MiddleName

-

Affiliation

Faculty of Pharmacy, Eastern Mediterranean University, 99628, Famagusta, North Cyprus via Mersin 10, Turkey

Email

j.yuzugulen@yahoo.com

City

-

Orcid

-

First Name

Majid

Last Name

Marjani

MiddleName

-

Affiliation

Faculty of Pharmacy, Eastern Mediterranean University, 99628, Famagusta, North Cyprus via Mersin 10, Turkey

Email

majiarjan@yahoo.com

City

-

Orcid

-

First Name

Abdoljalal

Last Name

Marjani

MiddleName

-

Affiliation

Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

Email

abdoljalal.marjani@yandex.com

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-

Orcid

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Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2021-02-02

Publish Date

2021-06-01

Page Start

139

Page End

148

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 139-148.pdf

PDF . 534.0kB

Link

https://bpsa.journals.ekb.eg/article_174139.html

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https://bpsa.journals.ekb.eg/service?article_code=174139

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14

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CYTOTOXIC EFFECT OF DEFINE CONCENTRATION OF YARROW (ACHILLEA MILLEFOLIUM) EXTRACT USED IN IRANIAN TRADITIONAL MEDICINE ON AGS HUMAN GASTRIC CANCER CELL-LINE

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Article

Created At

22 Jan 2023