Beta
ManageSearchChatDiscover
174138

ASSESSING THE EFFECTS OF ORLISTAT AS AN ANTI-OBESITY DRUG IN HIGH FAT DIET INDUCED OBESITY IN MALE RATS

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The present work was designed to evaluate the effectiveness of the orlistat drug on some hormones and biochemical parameters in male rats received a high fat diet (HFD). Twenty-four rats were divided into four groups: 1st group administered normal diet, 2nd group administered HFD, the 3rd group administered HFD plus 9.5 mg/kg b.w./day orlistat, and the 4th group administered HFD diet plus 19 mg/kg b.w./day orlistat. The experimental period was for four weeks. At the end of the experiment, blood samples were obtained for biochemical and hormonal assays. The administration of HFD for four weeks increased significantly the weight gain, serum total cholesterol (TC), triglycerides (TAG), low density lipoprotein (LDL-c), glucose, insulin, triiodothyronine (T3), thyroxine (T4), leptin, with the significant decrease in high density lipoprotein (HDL-c), ghrelin, thyrotropin (TSH) and testosterone hormones in the serum as compared with the control group. The treatment with orlistat neutralized the levels of the measured parameters as compared with HFD fed rats and the results were correlated with the dose of orlistat. In conclusion, an improvement was observed in the biochemical and hormonal results by the treatment with orlistat drug.

DOI

10.21608/bfsa.2021.174138

Authors

First Name

Enas

Last Name

Abdel-Baky

MiddleName

Saleh

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

enas_saleh@edu.asu.edu.eg

City

-

Orcid

-

First Name

Omnia

Last Name

Abdel-Rahman

MiddleName

Nasr

Affiliation

Department of Biological and Geological Sciences, Faculty of Education, Ain Shams University, Cairo, Egypt

Email

omnianasr@edu.asu.edu.eg

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2020-11-19

Publish Date

2021-06-01

Page Start

131

Page End

138

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 131-138.pdf

PDF . 334.2kB

Link

https://bpsa.journals.ekb.eg/article_174138.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=174138

Order

13

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSESSING THE EFFECTS OF ORLISTAT AS AN ANTI-OBESITY DRUG IN HIGH FAT DIET INDUCED OBESITY IN MALE RATS

Details

Type

Article

Created At

22 Jan 2023