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174132

IN-SILICO AND IN-VITRO BACTERICIDAL ACTIVITY OF THE PHYTOCHEMICALS OF PEPEROMIA PELLUCIDA (L.) HERB

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Last updated: 04 Jan 2025

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Abstract

Background: The development and spread of pathogenic antibiotic resistance to many antibiotics have been growing worldwide. This concept is of enormous importance, and it is crucial to identify appropriate therapeutic drugs to fight against these antibiotic-resistant microbes. Plant species can make a valuable contribution to new antibiotics to replace or improve existing treatment potential. Methods: In this work, we conducted a molecular modelling study of three phytochemicals (Peperomin A, Peperomin E, Peperomin F) with bacterial targets penicillin-binding protein (2C6W) from Streptococcus pneumoniae and kdpFABC complex (5MRW) of Escherichia coli. Peperomia pellucida methanolic extract was conducted antimicrobial activity against clinical Streptococcus pneumoniae and Escherichia coli. Results: Three phytochemicals (Peperomin A, Peperomin E, Peperomin F) showed the best docking results with target antimicrobial-resistant targets. Peperomia pellucida methanolic extract showed good antibacterial activity against clinical Streptococcus pneumoniae and Escherichia coli. Conclusion: In-vitro and In silico bactericidal studies conducted, Peperomia pellucida phytochemical has significance antibacterial activity against clinical Streptococcus pneumoniae, Escherichia coli.

DOI

10.21608/bfsa.2021.174132

Authors

First Name

V.

Last Name

Shilpa

MiddleName

P.

Affiliation

Department of Pharmaceutics, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India, 678702

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First Name

Wilson

Last Name

Viljeena

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Affiliation

Department of Pharmaceutics, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India, 678702

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First Name

E.

Last Name

Alby Babu

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Affiliation

Department of Pharmaceutics, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India, 678702

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First Name

Davis

Last Name

Nidhina

MiddleName

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Affiliation

Department of Pharmaceutics, Sanjo College of Pharmaceutical Studies, Vellapara, Palakkad, Kerala, India, 678702

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First Name

K.

Last Name

Muddukrishnaiah

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Affiliation

Department of Technology, Anna University, Chennai, Tamil Nadu, India

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Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2021-01-28

Publish Date

2021-06-01

Page Start

73

Page End

80

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 73-80.pdf

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https://bpsa.journals.ekb.eg/article_174132.html

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https://bpsa.journals.ekb.eg/service?article_code=174132

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

IN-SILICO AND IN-VITRO BACTERICIDAL ACTIVITY OF THE PHYTOCHEMICALS OF PEPEROMIA PELLUCIDA (L.) HERB

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Article

Created At

22 Jan 2023