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174126

ANTI-HYPERGLYCEMIC ACTIVITY OF TOTAL ETHANOLIC FRUIT EXTRACT OF FAIDHERBIA ALBIDA ON NICOTINAMIDE-STREPTOZOTOCIN-INDUCED DIABETIC MICE

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Last updated: 04 Jan 2025

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Abstract

Faidherbia albida is one of the plants that have been traditionally used throughout the world in the treatment of diabetes. In previous studies, various parts of the plant such as the methanolic root bark, aqueous seed, and the aqueous stem bark extracts have been tested on alloxan-induced diabetic rats for their anti-hyperglycemic activity. In the current study, the anti-hyperglycemic activity of the total ethanolic extract of Faidherbia albida fruits was evaluated in nicotinamide-streptozotocin-induced diabetic mice using glimepiride as a reference anti-diabetic drug. The total ethanolic fruit extract at 200 mg/kg body weight significantly (p < 0.05) lowered the blood glucose level in diabetic mice by (74%) after 4 hrs of oral administration while the peak hypoglycemic effect of glimepiride (55.2%) occurred at the 4th hr after oral administration. The results provided evidence that Faidherbia albida fruit extract is recommended to be used as a hypoglycemic drug in treating diabetic patients.

DOI

10.21608/bfsa.2021.174126

Authors

First Name

Rania

Last Name

Abdel-Emam

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut 71515, Egypt

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First Name

Marwa

Last Name

Mohammed

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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Orcid

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First Name

Ahmed

Last Name

Ali

MiddleName

A.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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Orcid

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First Name

Ezz-eldin

Last Name

Desoky

MiddleName

K.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

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City

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Orcid

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First Name

Lourin

Last Name

Malak

MiddleName

G.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2020-08-31

Publish Date

2021-06-01

Page Start

41

Page End

48

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 41-48.pdf

PDF . 418.2kB

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https://bpsa.journals.ekb.eg/article_174126.html

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https://bpsa.journals.ekb.eg/service?article_code=174126

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTI-HYPERGLYCEMIC ACTIVITY OF TOTAL ETHANOLIC FRUIT EXTRACT OF FAIDHERBIA ALBIDA ON NICOTINAMIDE-STREPTOZOTOCIN-INDUCED DIABETIC MICE

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Article

Created At

22 Jan 2023