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174122

FORMULATION DEVELOPMENT AND EVALUATION OF HIGHLY WATER-SOLUBLE DRUG-LOADED CONTROLLED RELEASE MATRIX TABLETS

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Last updated: 25 Dec 2024

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Abstract

Formulation of controlled release matrix tablets of Itopride hydrochloride (ITP) was done using direct compression method. Different polymers were used to evaluate the influence of different types (HPM, EC, Kollidon® SR), concentration (20-40%) and viscosity grade (HPMC-4000 cps, HPMC-100000 cps, EC-10 cps and Kollidon SR) on drug release. Twelve different tablet formulations were designed with constant amount of ITP in each tablet formulation (150 mg). The dissolution studies of CR matrix formulations were carried out in acidic buffer (pH 1.2) and phosphate buffer (pH 6.8). Drug release kinetics was studied for first order, Zero-order, Higuchi, Korsmeyer-Peppas and Weibull models using DD Solver (an add-in software for MS Excel). Formulation ECF7, ECF8 and ECF9 containing EC (20-40%) greatly controlled the release rate of drug over an extended period of 12 hr. However, drug release from tablets formulations K4F3, K100F5 and ECF8, followed zero-order kinetics with regression coefficient of 0.966-0.999. The release mechanism of tablets formulations K4F2, KK4F3, K4F4, ECF7, KSRF10, KSRF11 and KSRF12 were non-fickian diffusion, whereas the release mechanism from formulations K4F1, K100F5, K100F6, ECF8 and ECF9 were super case-II transport mechanism. It was concluded that HPMC and ethylcellulose (EC-10cps) in the percentage range of 20-30% were excellent release controlling polymers for itopride HCl.

DOI

10.21608/bfsa.2021.174122

Authors

First Name

Aqsa

Last Name

Siraj

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

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City

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Orcid

-

First Name

Muhammad

Last Name

Nasiri

MiddleName

Iqbal

Affiliation

Department of Pharmaceutics, Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Islamabad, Pakistan

Email

-

City

-

Orcid

-

First Name

Syed

Last Name

Naqvi

MiddleName

Baqir S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

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City

-

Orcid

-

First Name

Tariq

Last Name

Ali

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Dow University of Health Science, Karachi, Pakistan

Email

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City

-

Orcid

-

First Name

Rabia

Last Name

Yousaf

MiddleName

Ismail

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Pakistan

Email

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City

-

Orcid

-

First Name

Humera

Last Name

Sarwar

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

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City

-

Orcid

-

First Name

Muhammad

Last Name

Asghar

MiddleName

Arif

Affiliation

Department of Pharmaceutics, Institute of Pharmaceutical Sciences, Jinnah Sindh Medical University, Karachi, Pakistan

Email

-

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-

Orcid

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Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2021-01-25

Publish Date

2021-06-01

Page Start

15

Page End

29

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 15-29.pdf

PDF . 876.9kB

Link

https://bpsa.journals.ekb.eg/article_174122.html

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https://bpsa.journals.ekb.eg/service?article_code=174122

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMULATION DEVELOPMENT AND EVALUATION OF HIGHLY WATER-SOLUBLE DRUG-LOADED CONTROLLED RELEASE MATRIX TABLETS

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Article

Created At

22 Jan 2023