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174121

EFFECT OF ESSENTIAL OILS ON TRANSDERMAL PERMEATION OF METOPROLOL SUCCINATE

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Last updated: 25 Dec 2024

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Abstract

The objective of the present study was to prepare a matrix-type transdermal drug delivery system containing metoprolol succinate and to evaluate the effect of essential oils on transdermal permeation of drug. The solvent evaporation method was employed to fabricate transdermal patches of drug using HPMC K15M and Acrycoat L100 as polymers and polyethylene glycol 400 as a plasticizer. Prepared patches were subjected for evaluation of physical as well as physicochemical properties, moisture characteristics, and ex-vivo drug permeation studies. The results of physical characterization showed uniform casting and good appearance of patches. Satisfactory mechanical strength was revealed in the results of tensile strength and folding endurance. Ex-vivo permeation study indicated enhancing effect of essential oils on drug permeation through the skin. The maximum flux observed was 94 μg/cm2.hr achieved by formulation M3 containing lemongrass oil (20%). The results suggested that lemongrass oil was effective at higher concentration (20%) after 14 hrs of permeation while peppermint oil and eucalyptus oil were effective at low concentration (10%). Release kinetic suggested diffusion-controlled release of drug which followed the Korsmeyer-Peppas model. In conclusion, essential oils can be utilized as a safe and effective alternative for the permeation enhancement of drugs through transdermal delivery.

DOI

10.21608/bfsa.2021.174121

Authors

First Name

Kishorkumar

Last Name

Sorathia

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

krsorathia@yahoo.com

City

-

Orcid

0000-0003-3328-1091

First Name

Mehul

Last Name

Patel

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

mehulpatel.ph@ddu.ac.in

City

-

Orcid

-

First Name

Tejal

Last Name

Soni

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

tejalsoni.ph@ddu.ac.in

City

-

Orcid

-

First Name

Vidur

Last Name

Vaghasiya

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

vidurvaghasiya5298@gmail.com

City

-

Orcid

-

First Name

Jaydip

Last Name

Patel

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

-

City

-

Orcid

-

First Name

B. N.

Last Name

Suhagia

MiddleName

-

Affiliation

Faculty of Pharmacy, Dharmsinh Desai University, Nadiad, Gujarat-387001, India

Email

-

City

-

Orcid

-

Volume

44

Article Issue

1

Related Issue

25283

Issue Date

2021-06-01

Receive Date

2020-08-31

Publish Date

2021-06-01

Page Start

1

Page End

14

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 44_Issue 1_Pages 1-14.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_174121.html

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https://bpsa.journals.ekb.eg/service?article_code=174121

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF ESSENTIAL OILS ON TRANSDERMAL PERMEATION OF METOPROLOL SUCCINATE

Details

Type

Article

Created At

22 Jan 2023