ManageChatDiscover
127991

ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Acinetobacter baumannii (A. baumannii) infections became an emerging health concern in hospitals across the globe and are often related to nosocomial infections with poorer clinical outcomes in patients with prolonged hospital stay. Management of infections involves prompt identification of the infecting strain, isolating the source of infection, and proper choice of antibiotic regimen. However, resistance to first-line antimicrobial drugs, combined with a scarcity of equally effective alternatives, complicates the treatment of multidrug-resistant (MDR) A. baumannii. Presently, MDR A. baumannii may be a serious health concern in hospitals and long-term care facilities accounting for up to 20% of infections in intensive care units, and 7% of infections in patients who are physically connected to medical equipments. Immediate and sustained prevention efforts are needed to control the speed of incidence. Antibiotic use is largely under-regulated in Egypt leading to the emergence of resistant isolates. This review describes genetic markers and other factors that influence the incidence of MDR A. baumannii. Current and emerging treatments as well as infection control strategies are discussed.

DOI

10.21608/bfsa.2020.127991

Authors

First Name

Randa

Last Name

Abd-ElNasser

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt & Ministry of Health and Population, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Mona

Last Name

Abdel-Rahim

MiddleName

Hussein

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Manal

Last Name

Mahmoud

MiddleName

Ahmed

Affiliation

Department of Chest Diseases, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Amal

Last Name

Elkhawaga

MiddleName

Ahmed

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Hassnein

MiddleName

Mohamed

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-08-29

Publish Date

2020-12-01

Page Start

265

Page End

279

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 265-279.pdf

PDF . 652.9kB

Link

https://bpsa.journals.ekb.eg/article_127991.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=127991

Order

16

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTIBIOTIC RESISTANCE OF ACINETOBACTER BAUMANNII: AN URGENT NEED FOR NEW THERAPY AND INFECTION CONTROL

Details

Type

Article

Created At

22 Jan 2023