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127417

PROSPECTS FOR USING MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 AND p38 OF NERVE TISSUE PROGENITORS AS PHARMACOLOGICAL TARGETS FOR THE TREATMENT OF NEURODEGENERATION CAUSED BY ALCOHOL

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Last updated: 25 Dec 2024

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Abstract

We studied the possibility of using ERK1/2 inhibitor and p38 inhibitor to modulate the functions of nerve tissue precursor cells in ethanol-induced neurodegeneration. It has been found that in chronic alcoholization of mice both these pharmacological substances are able to increase proliferative activity of neural stem cells (NSC). In addition, the blockade of ERK1/2 initiates the progression of the cell cycle of the neuronal-committed progenitors (NCP, clonogenic PSA-NCAM + cells). This reduces the differentiation intensity of NSC and clonogenic PSA-NCAM + cells under the influence of the ERK1/2 inhibitor and such in NSC under the influence of p38 inhibitor. The fundamental difference between the functions of ERK1/2 and p38 in the regulation of the NSC and NCP cell cycle in optimal living conditions and in ethanol-induced neurodegeneration does not allow to draw unambiguous conclusions about the prospect of using these protein kinases as pharmacological targets of drugs for the therapy of alcoholic encephalopathy.

DOI

10.21608/bfsa.2020.127417

Authors

First Name

Gleb

Last Name

Zyuz'kov

MiddleName

N.

Affiliation

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia

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Orcid

-

First Name

Larisa

Last Name

Miroshnichenko

MiddleName

A.

Affiliation

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia

Email

laarmi@yandex.ru

City

-

Orcid

0000-0002-3684-5510

First Name

Elena

Last Name

Simanina

MiddleName

V.

Affiliation

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia

Email

elena_simanina@mail.ru

City

-

Orcid

0000-0003-1890-6946

First Name

Tatyana

Last Name

Polyakova

MiddleName

Yu.

Affiliation

Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia, 3 Lenin Prospect, Tomsk, 634028, Russia

Email

tasha93@mail.ru

City

-

Orcid

0000-0003-0971-7844

Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-06-15

Publish Date

2020-12-01

Page Start

217

Page End

224

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 217-224.pdf

PDF . 413.4kB

Link

https://bpsa.journals.ekb.eg/article_127417.html

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https://bpsa.journals.ekb.eg/service?article_code=127417

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12

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PROSPECTS FOR USING MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2 AND p38 OF NERVE TISSUE PROGENITORS AS PHARMACOLOGICAL TARGETS FOR THE TREATMENT OF NEURODEGENERATION CAUSED BY ALCOHOL

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Article

Created At

22 Jan 2023