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127415

PREDICTORS OF HCV SEROCONVERSION AMONG END-STAGE RENAL DISEASE PATIENTS IN HEMODIALYSIS UNIT

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Last updated: 04 Jan 2025

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Abstract

Background: In patients under dialysis, blood borne infections remains one of the mostpublic causes of morbidity, hospitalization and death. Among dialysis patient's long-term hemodialysis (HD) therapy, frequency of blood transfusions and multiple blood transfusions enhance the risk of acquiring blood-borne infections. Objective: The aim of the study was to identify predictors for HCV seroconversion in HD patients. Method: Prospective observational study was conducted on 173 Chronic kidney disease (CKD) patients undergoing HD. Anti HCV antibody testing was accomplished at the start of study and every 2-3 months subsequently. To identify seroconversion, patients who were sero-negative for HCV were monitored. Results: Prospective follow-up exposed an occurrence of seroconversion of 12.1% during study duration. On multivariate analysis, both increase in the duration on hemodialysis besides attending more than one centre for HD were significantly associated with anti-HCV positivity (p < 0.05, OR 0.185), (p < 0.05, OR 4.52) respectively. Risk factors blood transfusion and AST >40 IU/L also shows significant association for seroconversion (p < 0.05). Conclusion: It is concluded that increase post dialysis incidence of HCV occurs as specific guidelines for HCV infected patients were not followed. Regular surveillance for HCV infection helps dramatically in decreasing the spread of HCV in hemodialysis unit.

DOI

10.21608/bfsa.2020.127415

Authors

First Name

Fakhara

Last Name

Bukhari

MiddleName

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Affiliation

Department of Pharmacy, Quaid-I-Azam University, Islamabad, Pakistan

Email

drfakhara.bukhari@yahoo.com

City

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Orcid

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First Name

Ahmad

Last Name

Khan

MiddleName

-

Affiliation

Department of Pharmacy, Quaid-I-Azam University, Islamabad, Pakistan

Email

akhan@qau.edu.pk

City

-

Orcid

-

First Name

Tahir

Last Name

Mehmood

MiddleName

-

Affiliation

SNS, NUST, Islamabad, Paksitan

Email

-

City

-

Orcid

-

Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-08-27

Publish Date

2020-12-01

Page Start

199

Page End

208

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 199-208.pdf

PDF . 446.1kB

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https://bpsa.journals.ekb.eg/article_127415.html

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https://bpsa.journals.ekb.eg/service?article_code=127415

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PREDICTORS OF HCV SEROCONVERSION AMONG END-STAGE RENAL DISEASE PATIENTS IN HEMODIALYSIS UNIT

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Article

Created At

22 Jan 2023