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127408

ANTI-INFLAMMATORY ACTIVITY OF THE FOOD PLANT CALLIGONUM POLYGONOIDES L. FLAVONOIDS TARGETING NF-κB

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Last updated: 04 Jan 2025

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Abstract

Calligonum polygonoides L. subsp. comosum (Polygonaceae) is a wild shrub that grows on the sandy deserts of various regions in North Africa, Western Asia and Southern Europe. In some of Asian countries, the flower buds and young branches of the plant are used to prepare traditional food dishes. Also, different organs of C. polygonoides L. are used traditionally in treatment of stomach diseases. The isolation of anti-inflammatory lead compounds was performed by using different normal silica gel, reversed phase C-18, and sephadex LH-20 open columns. The identification of the isolated compounds was done using NMR spectral techniques. The isolated compounds are of different flavonoid classes; two flavonol glycosides; kaempferol-3-O-β-D-glucuronide and mequilianin, one flavan-3-ol; catechin, and one dihydro-flavonol; taxifolin. The methanol extract and ethyl acetate fraction of Calligonum polygonoides L. subsp. comosum exhibited anti-inflammatory activity against NF-κB translocation pathway on HEK293 cells. All of them were active against NF-κB translocation, and previously isolated from the plant under study. Kaempferol-3-O-β-D-glucuronide, a flavonoid glycoside demonstrated the most potent NF-κB inhibition in comparing with other flavonoids; taxifolin, catechin, and mequilianin. Therefore, the food plant aerial parts of C. polygonoides are rich in nutraceuticals (flavonoids and flavonoid glycosides) that can be utilized in the treatment of vascular inflammation.

DOI

10.21608/bfsa.2020.127408

Authors

First Name

Ahmed

Last Name

Zaher

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

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City

-

Orcid

-

First Name

Mai

Last Name

Ahmed

MiddleName

A. M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

mai179@yahoo.com

City

-

Orcid

-

First Name

Nesma

Last Name

Mohamed

MiddleName

M.

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

nesma.mohamed269@pharm.aun.edu.eg

City

-

Orcid

0000-0001-8357-6942

Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-09-17

Publish Date

2020-12-01

Page Start

157

Page End

164

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 157-164.pdf

PDF . 465.7kB

Link

https://bpsa.journals.ekb.eg/article_127408.html

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https://bpsa.journals.ekb.eg/service?article_code=127408

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTI-INFLAMMATORY ACTIVITY OF THE FOOD PLANT CALLIGONUM POLYGONOIDES L. FLAVONOIDS TARGETING NF-κB

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Article

Created At

22 Jan 2023