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127407

ARISTOLOCHIC ACID I DETERMINATION IN ARISTOLOCHIA CLEMATITIS L. RAW MATERIALS BY HPLC METHOD

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Last updated: 04 Jan 2025

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Abstract

Aristolochia clematitis has long ago been applied in Asian traditional medicine and demonstrates multidirectional pharmacological activity. Contemporary research has confirmed its expressed antimicrobial activity.
Using high performance liquid chromatography (HPLC) we ascertained and determined the content of aristolochic acid 1 in herb and roots of Aristolochia clematitis collected within the blooming period in Kharkiv and Khmelnytskyi Regions, Ukraine. As aristolochic acid I causes nephrotoxic activity of plants, particularly, Aristolochia clematitis, it is quite mandatory to control its content in raw materials. The content of aristolochic acid I in Aristolochia clematitis herb was 0.11±0.01%, in roots its content was 0.14±0.01%. Thus, issuing from the results of our experiment, we concluded that Aristolochia clematitis raw materials may be treated as feasible for the development of drugs, but only for external application. The results of our study may be used for the development of Aristolochia clematitis raw materials standardization parameters and safe application.

DOI

10.21608/bfsa.2020.127407

Authors

First Name

Lala

Last Name

Pohodina

MiddleName

-

Affiliation

Department of Chemistry of Natural Compounds and Nutritiology, National University of Pharmacy, Kharkiv, Ukraine

Email

pogodinalala@gmail.com

City

-

Orcid

0000-0003-4547-2776

First Name

Nadiia

Last Name

Burda

MiddleName

-

Affiliation

Department of Chemistry of Natural Compounds and Nutritiology, National University of Pharmacy, Kharkiv, Ukraine

Email

nadegdaburda@ukr.net

City

-

Orcid

0000-0002-7435-5731

First Name

Viktoriia

Last Name

Kyslychenko

MiddleName

-

Affiliation

Department of Chemistry of Natural Compounds and Nutritiology, National University of Pharmacy, Kharkiv, Ukraine

Email

cncvc55@gmail.com

City

-

Orcid

0000-0002-0851-209X

First Name

Larisa

Last Name

Andryukova

MiddleName

-

Affiliation

Department of Industrial Pharmacy and Economics, National University of Pharmacy, Kharkiv, Ukraine

Email

larisanikand@gmail.com

City

-

Orcid

0000-0002-8705-9042

First Name

Artur

Last Name

Martynov

MiddleName

-

Affiliation

Mechnikov Institute of Microbiology and Immunology, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine

Email

imiamn@gmail.com

City

-

Orcid

0000-0003-1428-0085

Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-08-12

Publish Date

2020-12-01

Page Start

149

Page End

155

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 149-155.pdf

PDF . 451.6kB

Link

https://bpsa.journals.ekb.eg/article_127407.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=127407

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5

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ARISTOLOCHIC ACID I DETERMINATION IN ARISTOLOCHIA CLEMATITIS L. RAW MATERIALS BY HPLC METHOD

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Article

Created At

22 Jan 2023