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127397

DEVELOPMENT AND OPTIMIZATION OF ALBENDAZOLE NANOSUSPENSION AS LOCAL ADJUVANT THERAPY FOR TREATMENT OF ENTEROBIASIS

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Last updated: 04 Jan 2025

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Abstract

The aim was to develop an optimized albendazole (ALB) nanosuspension to improve its solubility and therapeutic activity as an adjuvant localized therapy for treatment of the pinworm infection to enhance oral treatment outcomes using Box–Behnken design. ALB-nanosuspensions were successfully prepared by antisolvent sono-precipitation technique considering amount of Lecithin, PVP and ultrasonication time as independent variables. All the formulations were characterized regarding their particle size and PDI (dependent variables).
Nanoparticle size was significantly increased by increasing lecithin and PVP concentrations while sonication time showed no influence. PDI of the nanosuspension was insignificantly decreased with increasing lecithin concentration and probe-sonication time. Optimum formulation was identified and subjected to solid phase characterization and morphological studies. ALB nanosuspension showed 10 folds increase in solubility over pure albendazole powder. Eventually, we studied the anthelmintic activity of ALB nanosuspension compared to free ALB where nanosuspension treated group showed lesser paralysis and death time than free ALB.

DOI

10.21608/bfsa.2020.127397

Authors

First Name

Aml

Last Name

Mekkawy

MiddleName

I.

Affiliation

Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Egypt

Email

aml.mekkawy@pharm.sohag.edu.eg

City

-

Orcid

-

First Name

Gihan

Last Name

Fetih

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt & Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Mahmoud

Last Name

EL-Badry

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt & Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Ayat

Last Name

Allam

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt & Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut, Egypt

Email

allamayat@yahoo.com

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Volume

43

Article Issue

2

Related Issue

19039

Issue Date

2020-12-01

Receive Date

2020-09-05

Publish Date

2020-12-01

Page Start

123

Page End

134

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 2_Pages 123-134.pdf

PDF . 875.7kB

Link

https://bpsa.journals.ekb.eg/article_127397.html

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https://bpsa.journals.ekb.eg/service?article_code=127397

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DEVELOPMENT AND OPTIMIZATION OF ALBENDAZOLE NANOSUSPENSION AS LOCAL ADJUVANT THERAPY FOR TREATMENT OF ENTEROBIASIS

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Article

Created At

22 Jan 2023