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104914

SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS

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Last updated: 25 Dec 2024

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Abstract

A spectrophotometric method is described for the determination of some N-ethyl drugs via reaction with chloranil. A mixture of a solution of' the amine in benzene with the chromogenic reagent was heated on a water bath at 75-80° for one hour. A blue colored product lmax 680 nm resulted. Apparent molar absorptivities of the chromogenic product of tertiary N-ethyl compounds ranged from 1700-5100. Under the described assay conditions N-methyl as well as quaternized N-ethyl compounds did not interfere. The amines are asseyed in the range of 0.004 - 1.3 mg per ml range with an accuracy of 99-101% recovery and a S.D. of ± 0.74- ± 3.11.%. The possible composition of the colored product is discussed.

DOI

10.21608/bfsa.1978.104914

Authors

First Name

M.

Last Name

Abdelkader

MiddleName

Atef

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Aly

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

163

Page End

174

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 163-174.pdf

PDF . 526.2kB

Link

https://bpsa.journals.ekb.eg/article_104914.html

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https://bpsa.journals.ekb.eg/service?article_code=104914

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11

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SENSITIVE AND SPECIFIC PHOTOMETRIC DETERMINATION OF N-ETHYL DRUGS

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Article

Created At

22 Jan 2023