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104913

ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES

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Last updated: 04 Jan 2025

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Abstract

The present study was aimed at evaluating the anti-inflammatory action and toxicity of seven N-[-l-(p-nitrophenyl)-l,3-dihydroxy isopropyl]-N'-(substituted) oxamides (1). The compounds are designed to include the following moieties: anthranilic and p-aminosalicylic acids and p-aminophenol in their basic structures. Two dose levels of these compounds were assessed for their anti--inflammatory property in rate by the trypan blue method and using acetyl salicylic acid as the reference anti-inflammatory agent. Median lethal doses of the compounds were determined in mice. The possible correlation between structure and biological activity is suggested.

DOI

10.21608/bfsa.1978.104913

Authors

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A.

Last Name

El-Koussi

MiddleName

A.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Abdel-Aleem

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Afifi

MiddleName

M.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

151

Page End

161

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 151-161.pdf

PDF . 446.6kB

Link

https://bpsa.journals.ekb.eg/article_104913.html

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https://bpsa.journals.ekb.eg/service?article_code=104913

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANTI-INFLAMMATORY ACTION AND TOXICITY OF CERTAIN OXAMIDE DERIVATIVES

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Article

Created At

22 Jan 2023