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104912

BIOAVAILABILITY OF TETRACYCLINE, TETRACYCLINE HYDROCHLORIDE AND COMPLEXES

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Last updated: 25 Dec 2024

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Abstract

The irregular and incomplete absorption of tetracycline from the GIT, directs the attention to use the organic complexes of this compound in therapy. Tetracycline complexes with urea, gentisic and pyrocatechuic acids were prepared and investigated in comparison with both tetracycline base and its hydrochloride salt. No correlation was found between the in-vitro results of lipophilicity of tetracycline base and its complexes and their availability. However, a correlation existed between the in-vitro T50% dissolution of tetracycline base, tetracycline hydrochloride and its complexes in distilled water adjusted to pH 2 and their cumulative urinary excretion by human volunteers. The impaired absorption of tetracycline when administered with milk was found to be greatly reduced in case of tetracycline hydrochloride, while the absorption of tetracycline-pyrocatechuic and gentisic acids complexes were the least affected.

DOI

10.21608/bfsa.1978.104912

Authors

First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

-

Orcid

-

First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Youssef

MiddleName

K.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

133

Page End

149

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 133-149.pdf

PDF . 566.1kB

Link

https://bpsa.journals.ekb.eg/article_104912.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104912

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

BIOAVAILABILITY OF TETRACYCLINE, TETRACYCLINE HYDROCHLORIDE AND COMPLEXES

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Article

Created At

22 Jan 2023