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104911

ANALYSIS AND DISSOCIATION OF CERTAIN ACIDIC PHARMACEUTICAL COMPOUNDS IN N-BUTANOL

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Last updated: 04 Jan 2025

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Abstract

Visual and potentiometric titrations of aspirin, benzoic acid, hydrochloric acid, nicotinic acid, perchloric acid, phenyl butazone, salicylic acid, chloropromazine hydrochloride, ephedrine hydrochloride, mepyramine maleate and procaine hydrochloride were carried out in n-butanol, using potassium butoxide as the titrant. For visual end points, thymol blue was used as indicator, while potentiometric measurements were assessed by a glass indicator electrode. The dissociation constants of' the studied compounds were determined by the use of the electromotive force method and revealed the good applicability of n-butanol as a solvent for non-aqueous titration of acidic pharmaceutical compounds.

DOI

10.21608/bfsa.1978.104911

Authors

First Name

Nawal

Last Name

El-Rabbat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Orcid

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First Name

Mahmoud

Last Name

El-Gendy

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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City

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Orcid

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First Name

Kamla

Last Name

Emara

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Orcid

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

115

Page End

131

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 115-131.pdf

PDF . 504.1kB

Link

https://bpsa.journals.ekb.eg/article_104911.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104911

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ANALYSIS AND DISSOCIATION OF CERTAIN ACIDIC PHARMACEUTICAL COMPOUNDS IN N-BUTANOL

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Article

Created At

22 Jan 2023