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104908

FORMAZAN-INDUCED COLORIMETRIC ANALYSIS OF DIHYDRALAZINE SULFATE

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Last updated: 04 Jan 2025

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Abstract

A colorimetric assay procedure was developed for the quantitativ analysis of dihydralazine sulfate. The method is based-on the interaction of 2,3,5-triphenyltetrazolium chloride with dihydralazine sulfate, in presence of potassium hydroxide in absolute ethanol, to afford a highly colored and stable formazan. This could be spectrophotometrically quantified at 485 nm, with an ideal adherence to Beer's law for solutions containing 2.0-22.0 mcg dihydralazine sulfate/ml. The presented color reaction is selective; no interference could be displayed by reserpine or hydrochlorothiazide. This permitted the application of the procedure to the satisfactory analysis of commercial dihydralazine formulations without prior separation from these drugs.

DOI

10.21608/bfsa.1978.104908

Authors

First Name

Nawal

Last Name

El-Rabbat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Nabil

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

73

Page End

86

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 73-86.pdf

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Link

https://bpsa.journals.ekb.eg/article_104908.html

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https://bpsa.journals.ekb.eg/service?article_code=104908

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

FORMAZAN-INDUCED COLORIMETRIC ANALYSIS OF DIHYDRALAZINE SULFATE

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Article

Created At

22 Jan 2023