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104907

A PAPER CHROMATOGRAPHIC METHOD FOR STABILITY INDICATING ASSAY OF THIAMINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

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Last updated: 04 Jan 2025

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Abstract

Paper chromatographic separation of thiamine hydrochloride from its degradation products has been successfully carried out on Whatmann No. 1 chromatographic paper using n-butanol, acetic acid, acetone, water (45:20:10:25) as the developing system. For quantitative determination, the separated vitamin was eluted with acidic potassium chloride solution and determined spectrophotometrically at 250 nm. The recovery of thiamine hydrochloride was found to be satisfactory, (S.D. = 0.1017 & C.V. = 1.0184). The method was successfully applied for the determination of thiamine hydrochloride in synthetic mixtures and in single and multicomponent pharmaceutical products with good precision and almost complete recoveries.

DOI

10.21608/bfsa.1978.104907

Authors

First Name

A.

Last Name

Sina

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Shawky

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

53

Page End

72

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 53-72.pdf

PDF . 726.1kB

Link

https://bpsa.journals.ekb.eg/article_104907.html

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https://bpsa.journals.ekb.eg/service?article_code=104907

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A PAPER CHROMATOGRAPHIC METHOD FOR STABILITY INDICATING ASSAY OF THIAMINE HYDROCHLORIDE IN PHARMACEUTICAL PREPARATIONS

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Article

Created At

22 Jan 2023