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104906

AN IMPROVED COLORIMETRIC DETERMINATION OF ANTAZOLINE

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Last updated: 04 Jan 2025

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Abstract

A simple, precise and accurate spectrophotometric determination of antazoline salts is developed by improvement of the previously reported ceric sulfate procedure. Replacement of glacial acetic acid for water in preparing all assay solutions enabled the reproducible measurement of the chromogen absorbing at 505 nm. An appreciable increase in color stability was attained by the controlled addition of perchloric acid to the cerie sulfate solution, prior to interaction with antazoline at room temperature. Evidence is provided to account for the oxidation of antazoline-aniline moiety on the expense of an anionic ceric species. No interference with the investigated color reaction was offered by other 2-imidazolines or phenylephrine. Added to the considerably high value of chromogen molar absorptivity, ideal adherence of color absorption to Beer's law permitted the accurate and reproducible estimation of antazoline over the1-10 mcg/ml concentration range. Application of the improved procedure to the satisfactory analysis of different antazoline dosage forms was also effected.

DOI

10.21608/bfsa.1978.104906

Authors

First Name

Nabil

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Assiut, Assiut, Egypt

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

35

Page End

51

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 35-51.pdf

PDF . 654.0kB

Link

https://bpsa.journals.ekb.eg/article_104906.html

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https://bpsa.journals.ekb.eg/service?article_code=104906

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

AN IMPROVED COLORIMETRIC DETERMINATION OF ANTAZOLINE

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Article

Created At

22 Jan 2023