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104905

DIRECT COLORIMETRIC ANALYSIS OF STILBESTROL DIPROPIONATE

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Last updated: 04 Jan 2025

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Abstract

A convenient and specific spectrophotometric determination of stilbestrol and stilbestrol dipropionate is developed by interaction with 2,3,5-triphenyltetrazolium chloride at 50°C for 45 minutes and subsequent measurement of the color formed at 485 nm. Evidence is provided to account for the significance of extended conjugation of 4,4'-stilbenediol derivatives to induce this color reaction. Ideal adherence of color absorption to Beer's law permitted accurate and precise determination of stilbestrol and stilbestrol dipropionate pure forms over a range of 2-22 mcg stilbestrol/ml. Application of the tetrazolium, reaction to the analysis of stilbestrol dipropionate oily dosage forms could be satisfactorily effected without prior hydrolytic or extraction processes. This offers a fundamental achievement for utility of the proposed procedure in automated analysis.

DOI

10.21608/bfsa.1978.104905

Authors

First Name

Nabil

Last Name

Omar

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Nawal

Last Name

El-Rabbat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

1

Article Issue

1

Related Issue

15892

Issue Date

1978-12-01

Publish Date

1978-12-31

Page Start

15

Page End

33

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 1_Issue 1_Pages 15-33.pdf

PDF . 688.9kB

Link

https://bpsa.journals.ekb.eg/article_104905.html

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https://bpsa.journals.ekb.eg/service?article_code=104905

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DIRECT COLORIMETRIC ANALYSIS OF STILBESTROL DIPROPIONATE

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Article

Created At

22 Jan 2023