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104852

SELECTIVE CHROMATOGRAPHIC DETECTION OF TERTIARY N-ETHYL DRUGS

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Last updated: 25 Dec 2024

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Abstract

There are reagents available for the detection of basic drugs in general on paper and thin layer chromatograms. However, reagents selective for specific groups of basic drugs are few and usually differentiate compounds with grossly different structural features. There are no reagents available to differentiate tertiary, N-ethyl drugs from their N-methyl analogues. These compounds have common occurance among pharmaceuticals and are frequently prescribed in the same dosage form (e.g, cough, mixture containing N-ethyl antitussive with N-methyl antihistamine or an ephedrine analogue). N-methyl and N-ethyl compounds usually have close pKa values and similar solubility characteristics. This renders clear-cut separation in paper chromatography (PC) or thin layer chromatography (TLC) not always feasible. Thus identification of either type through Rf-values alone is not decisive.

DOI

10.21608/bfsa.1979.104852

Authors

First Name

Aly

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Abdel-Kader

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

2

Article Issue

1

Related Issue

15889

Issue Date

1979-12-01

Publish Date

1979-12-31

Page Start

69

Page End

75

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 2_Issue 1_Pages 69-75.pdf

PDF . 297.9kB

Link

https://bpsa.journals.ekb.eg/article_104852.html

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https://bpsa.journals.ekb.eg/service?article_code=104852

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SELECTIVE CHROMATOGRAPHIC DETECTION OF TERTIARY N-ETHYL DRUGS

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Article

Created At

22 Jan 2023