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104851

ASSAY OF 3-SUBSTITUTED PYRIDINES THROUGH FUJIWARA REACTION

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Last updated: 25 Dec 2024

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Abstract

3-Substituted pyridines of pharmaceutical interest with a carbonyl group in the 3-position have been determined by a modification of the Koenig's reaction without interferences from the 2-and 4-substituted isomers. Nicotinic acid, nicotinamide, and nikethamide in a strongly alkaline medium were reacted with chlorbutol in absolute ethanol on a steam bath for 5 minutes. The reaction mixture was cooled in ice bath and the pH was adjusted. The chromogen was developed by the use of a solution of thiobarbituric acid, barbituric acid or benzidine dihydrochloride where a stable color was formed showing a prominent absorption peaks at 535, 580, and 525 nm respectively. The relationship between absorbance and concentration is linear in the range of 0.005 - 0.05 mg per ml for nicotinic acid, and 0.01-0.1 g per ml for nicotinamide and nikethamide. The selectivity of the method within the 3-substituted members was also investigated.

DOI

10.21608/bfsa.1979.104851

Authors

First Name

M.

Last Name

Abdel-Kader

MiddleName

Atef

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

Aly

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

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First Name

S.

Last Name

Abdel-Fattah

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

2

Article Issue

1

Related Issue

15889

Issue Date

1979-12-01

Publish Date

1979-12-31

Page Start

59

Page End

68

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 2_Issue 1_Pages 59-68.pdf

PDF . 378.8kB

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https://bpsa.journals.ekb.eg/article_104851.html

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https://bpsa.journals.ekb.eg/service?article_code=104851

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

ASSAY OF 3-SUBSTITUTED PYRIDINES THROUGH FUJIWARA REACTION

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Article

Created At

22 Jan 2023