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104847

DETERMINATION OF THE CMC OF SELECTED SURFACTANT SOLUTIONS IN SYSTEMS CONTAINING CHLORAMPHENICOL

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Last updated: 25 Dec 2024

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Abstract

The solubility of Chloramphenicol was determined in solutions containing the following non-ionic surfactants: Tween 20, Tween 40, Tween  60, Emulgin C 1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59 together with cetrimide and sodium lauryl sulphate as representative examples for cationic and anionic surfactants. The solubilizing capacity of the different surfactant solutions above and below their CMC values were determined. It was concluded that all these surfactants when present in concentrations less than their CMC failed to enhance the solubility of chloramphenicol. The cationic and anionic surfactants showed the most significant increase in the drug solubility than the non-ionic surfactants above their CMC. The CMC values reported for the different classes of surfactants were found to be slightly different from literature reports.

DOI

10.21608/bfsa.1979.104847

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Sakr

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

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Orcid

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First Name

A.

Last Name

Abdelzaher

MiddleName

-

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

2

Article Issue

1

Related Issue

15889

Issue Date

1979-12-01

Publish Date

1979-12-31

Page Start

27

Page End

39

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 2_Issue 1_Pages 27-39.pdf

PDF . 381.3kB

Link

https://bpsa.journals.ekb.eg/article_104847.html

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https://bpsa.journals.ekb.eg/service?article_code=104847

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

DETERMINATION OF THE CMC OF SELECTED SURFACTANT SOLUTIONS IN SYSTEMS CONTAINING CHLORAMPHENICOL

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Article

Created At

22 Jan 2023