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104845

STUDIES ON SOME FACTORS AFFECTING THE STABILITY OF RIFAMPICIN IN SOLUTION

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Last updated: 25 Dec 2024

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Abstract

Rifampicin stability in relation to a number of factors namely; solvent type, pH value, type of buffering system, ionic strength and storage temperature was investigated. Kinetic treatment of the obtained data revealed first order pattern for rifampicin degradation. The degradation rate constant varied according to the type of the solvent, the pH of the solution, the type of the buffering components, the ionic strength and the storage temperature. Degradation was accelerated in solvents of higher dielectric constants in contrast to those of lower dielectric constants. The pH for minimal degradation was found to be pH 6.  Rifampicin degradation proceeded at minimal rate in presence of ascorbate buffer compared to formate, acetate, phosphate, Sorensens phosphate and Mcilvaine's citric acid-phosphate buffering systems. The calculated activation energy (Ea) and frequency factors of rifampicin was 15.47 K. cal/mol and 2.16 x 109 day-1 respectively.

DOI

10.21608/bfsa.1979.104845

Authors

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

I.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

S.

Last Name

Mohamed

MiddleName

I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

2

Article Issue

1

Related Issue

15889

Issue Date

1979-12-01

Publish Date

1979-12-31

Page Start

11

Page End

25

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 2_Issue 1_Pages 11-25.pdf

PDF . 437.7kB

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https://bpsa.journals.ekb.eg/article_104845.html

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https://bpsa.journals.ekb.eg/service?article_code=104845

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDIES ON SOME FACTORS AFFECTING THE STABILITY OF RIFAMPICIN IN SOLUTION

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Article

Created At

22 Jan 2023