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104723

RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE

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Last updated: 04 Jan 2025

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Abstract

A simple, rapid, selective and highly sensitive colorimetric method for the determination of isoprenaline (isoproterenol) is described. The method depends on the interaction of dimethoxydiquinone, with isoprenaline sulphate under specified conditions with the formation of a highly coloured, product which has a lmax at 5l0 nm and apparent molar absorptivity of 3.8x106. Absorbance versus concentration is linear up to 6 mcg/ml. No interference is observed in presense of common pharmaceutical adjuvants. The developed method is applicable with almost complete recovery for assaying isoprenaline in commercial, pharmaceutical dosage forms without prior separation. The proposed method is also recommended as stability indicating assay for oxidative degradation involving the catecholic  function of isoprenaline.

DOI

10.21608/bfsa.1980.104723

Authors

First Name

Salwa

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

3

Article Issue

1

Related Issue

15863

Issue Date

1980-12-01

Publish Date

1980-12-31

Page Start

125

Page End

136

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 3_Issue 1_Pages 125-136.pdf

PDF . 437.2kB

Link

https://bpsa.journals.ekb.eg/article_104723.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104723

Order

11

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RAPID, SENSITIVE COLORIMETRIC ASSAY FOR ISOPRENALINE

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Article

Created At

22 Jan 2023