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104721

SENSITIVE AND SPECIFIC ASSAY OF TERTIARY AMINE DRUGS WITH PHTHALIC ANHYDRIDE

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Last updated: 25 Dec 2024

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Abstract

The reaction of tertiary amines with phthalic anhydride/acetic anhydride mixture was studied and developed into a sensitive assay for the amines. The method is based on the condensation of the two anhydrides under the catalytic effect of the tertiary amine function, either free or in the form of a salt. The condensation product had a lmax at 302 nm for all the drugs tested with apparent molar absorptivitis in the range 5.79 x 104- 1.08 x 105. Absorption Versus concentration was found linear up to about 6 mcg/ml for all drugs studied. The method has been applied for the analysis of certain tertiary amine drugs belonging to different pharmacological groups e.g. pilocarpine nitrate, butethamat citrate, atropine sulphate, bietamiverine dihydrochloride, codeine phosphate and toclase citrate in pure form as well as in pharmaceutical preparations without prior separation and with good accuracy (100 38%), recoveries and precision (SD ± 0.41).

DOI

10.21608/bfsa.1980.104721

Authors

First Name

Aly

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut

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Orcid

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First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Rageh

MiddleName

I.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut

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City

-

Orcid

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Volume

3

Article Issue

1

Related Issue

15863

Issue Date

1980-12-01

Publish Date

1980-12-31

Page Start

105

Page End

115

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 3_Issue 1_Pages 105-115.pdf

PDF . 376.9kB

Link

https://bpsa.journals.ekb.eg/article_104721.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104721

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9

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SENSITIVE AND SPECIFIC ASSAY OF TERTIARY AMINE DRUGS WITH PHTHALIC ANHYDRIDE

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Article

Created At

22 Jan 2023