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104713

A STUDY ON THE RELATIONSHIP BETWEEN DISINTEGRATION OF DIRECTLY COMPRESSED SULPHADIMIDINE TABLETS AND THEIR PHYSIOLOGICAL AVAILABILITY IN MAN

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Last updated: 25 Dec 2024

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Abstract

 A study was made on the disintegration time and in vivo absorption rate of sulphadimidine tablets prepared by direct compression technique using Celutab (50% w/w) as an excipient. Tablets of greatly different disintegration times were selected for this investigation. Using urinary excretion method, it was shown that there is a relationship between disintegration time and in vivo absorption of sulphadimidine tablets, in that the tablet with faster disintegration time gives a higher absorption as indicated by the excretion rate calculated from the cummulative amount of sulphadimidine excreted.

DOI

10.21608/bfsa.1980.104713

Authors

First Name

Adel

Last Name

Sakr

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

Ahmed

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hassan

Last Name

Elsabbagh

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Adel

Last Name

Aly

MiddleName

M.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

15863

Issue Date

1980-12-01

Publish Date

1980-12-31

Page Start

74

Page End

86

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 3_Issue 1_Pages 74-86.pdf

PDF . 425.3kB

Link

https://bpsa.journals.ekb.eg/article_104713.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104713

Order

7

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

A STUDY ON THE RELATIONSHIP BETWEEN DISINTEGRATION OF DIRECTLY COMPRESSED SULPHADIMIDINE TABLETS AND THEIR PHYSIOLOGICAL AVAILABILITY IN MAN

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Article

Created At

22 Jan 2023