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104712

EFFECT OF SURFACTANT STRUCTURE ON THE RELEASE OF DEXAMETHAZONE FROM DIFFERENT OINTMENT BASES

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Last updated: 25 Dec 2024

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Abstract

The effect of variations in the surfactant molecular Structure and concentration on the release of dexamethazone from different ointment bases, was investigated. It was found that the release of dexamethazone from oil in water emulsion bases increased in the presence of the different hydrophilic non-ionic surfactants used: This may be due to their solubilizing effect on such slightly water soluble solute. The increase in surfactant concentration enhanced the rate of drug released from each base by a special rate, specific for each base. The incorporation of hydrophobic surfactants in the water in oi1, emulsion bases leads also to increase in the amount of drug released. This may be due to the dispersing effect of these surfactants on such a drug.

DOI

10.21608/bfsa.1980.104712

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

-

First Name

A.

Last Name

Abotaleb

MiddleName

E.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

3

Article Issue

1

Related Issue

15863

Issue Date

1980-12-01

Publish Date

1980-12-31

Page Start

59

Page End

73

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 3_Issue 1_Pages 59-73.pdf

PDF . 352.9kB

Link

https://bpsa.journals.ekb.eg/article_104712.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=104712

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SURFACTANT STRUCTURE ON THE RELEASE OF DEXAMETHAZONE FROM DIFFERENT OINTMENT BASES

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Article

Created At

22 Jan 2023