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104711

STUDIES ON THE SOLUBILITY OF RIFAMPICIN. II. EFFECT OF SOME AROMATIC MONOCARBOXYLIC ACIDS SODIUM SALTS, NICOTINAMIDE AND ISONIAZID ON THE WATER-SOLUBILITY OF RIFAMPICIN

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Last updated: 04 Jan 2025

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Abstract

The effect of some salts of aromatic monocarboxylic acids namely, sodium benzoate, sodium p-aminolenzoate, sodium salicylate and sodium p-aminosalioylate as well as nicotinamide and isoniazid on the water solubility of rifampicin was investigated. The apparent, water-solubility of rifampicin is augmented markedly in presence of these agents. The solubilizing power of these agents towards rifampicin is highly dependent on the specific type and in most cases proportional to the concentration of the agent, of the salts of the aromatic monocarboxylic acids, sodium p-aminosalicylate showed the highest solubilizing power followed in order by sodium salicylate, sodium p-aminobenzoate and finally sodium benzoate with the least solubilizing power. Nicotinamide showed higher solubilizing power than that of isoniazid but much less than that of sodium p-aminosalicylate and sodium salicylate. The solubilizing power of isoniazid is greater than that of sodium benzoate and sodium p-aminobenzoate. The spectral pattern of rifampicin showed a change in optical density in presence of these agents which is proportional to the agent used, suggesting a role of molecular interaction between these agents and rifampicin in the solubilization process.

DOI

10.21608/bfsa.1980.104711

Authors

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S.

Last Name

lbrabim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

I.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

Orcid

-

First Name

S.

Last Name

Mohamed

MiddleName

I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

3

Article Issue

1

Related Issue

15863

Issue Date

1980-12-01

Publish Date

1980-12-31

Page Start

41

Page End

58

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 3_Issue 1_Pages 41-58.pdf

PDF . 557.7kB

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https://bpsa.journals.ekb.eg/article_104711.html

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https://bpsa.journals.ekb.eg/service?article_code=104711

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

STUDIES ON THE SOLUBILITY OF RIFAMPICIN. II. EFFECT OF SOME AROMATIC MONOCARBOXYLIC ACIDS SODIUM SALTS, NICOTINAMIDE AND ISONIAZID ON THE WATER-SOLUBILITY OF RIFAMPICIN

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Article

Created At

22 Jan 2023