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104594

THE USE OF MOLECULAR SIEVE TECHNIQUE FOR STUDYING UNDERSATURATED SYSTEMS CONTAINING CHLORAMPHENICOL

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Last updated: 04 Jan 2025

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Abstract

Molecular sieve technique was carried out using sephadex G 25 fine for investigating the under-saturated systems containing chloramphenicol. This drug was solubilized by a series of commerical non-ionic surfactants which include: Tween 20, Tween 40, Tween 60, Tween 80, EmulginC1000, Emulgin C1500, Myrj 52, Myrj 53 and Myrj 59. At two different temperatures 25 and 35° it was found that the amount of chloramphenicol incorporated within the micelle as calculated by the molecular sieve technique was greater for Emulgin 1000 than Emulgin 1500, on the other hand for Tween series the following sequence was obtained: Tween 80 > Tween 40 > Tween 60 > Tween 20. For Myrj series Myrj 52 was greater than Myrj 53 which in turn was higher than Myrj 59. The results obtained by investigating the under-saturated systems using this technique agreed with those determined by solubility method and gave further support to the partition model of solubilization and prove the validity of using this technique for investigating undersaturated solubilized systems containing non-ionic surfactants.

DOI

10.21608/bfsa.1981.104594

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Abdelzaher

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Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Volume

4

Article Issue

1

Related Issue

15861

Issue Date

1981-12-01

Publish Date

1981-12-31

Page Start

133

Page End

150

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 4_Issue 1_Pages 133-150.pdf

PDF . 589.9kB

Link

https://bpsa.journals.ekb.eg/article_104594.html

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https://bpsa.journals.ekb.eg/service?article_code=104594

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE USE OF MOLECULAR SIEVE TECHNIQUE FOR STUDYING UNDERSATURATED SYSTEMS CONTAINING CHLORAMPHENICOL

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Article

Created At

22 Jan 2023