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104592

AN INVESTIGATION ON THE DISSOLUTION OF NITROFURANTOIN

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Last updated: 04 Jan 2025

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Abstract

The problem of the existence of interlot and inter-tablet variation in the dissolution rates of nitrofurantion (NFT) marketed tablets, attracts, the attention for investigating the microcrystalline NFT powder used in formu1ating the marketed tablet products. The x-ray diffractometry and the differential, scanning colorimetry of five microcrystalline NFT powders obtained from different manufacturers revealed that this drug is not exhibiting polymorphism. NFT hydrates of large particle size were observed to be formed when the drug was to be in contact with water with the pH values in the acidic range. The unexpected dissolution - PH profile of stored NFT suspensions prepared by precipitation at pH 5.4 from alkaline solution may be illustrated by the possibility of tautomeric transformations in the drug. This was more revealed by the observed reversible shift of the l maxima on changing the pH of its solutions.

DOI

10.21608/bfsa.1981.104592

Authors

First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

A.

Last Name

Sina

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

S.

Last Name

Ibrahim

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

K.

Last Name

Khaled

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

15861

Issue Date

1981-12-01

Publish Date

1981-12-31

Page Start

99

Page End

119

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 4_Issue 1_Pages 99-119.pdf

PDF . 541.6kB

Link

https://bpsa.journals.ekb.eg/article_104592.html

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https://bpsa.journals.ekb.eg/service?article_code=104592

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8

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

AN INVESTIGATION ON THE DISSOLUTION OF NITROFURANTOIN

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Article

Created At

22 Jan 2023