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104591

RELEASE AND RHEOLOGICAL CHARACTERISTICS OF CHLORTETRACYCLINE HYDROCHLORIDE OPHTHALMIC OINTMENTS

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Last updated: 04 Jan 2025

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Abstract

The release of chlortetracycline from absorption and emulsion ointment bases were studied. The drug release rates from the emulsion bases were found to be Higher than that from the absorption bases. The presence of sod. metabisulphite and EDTA in the ointment systems under test was found to increase the release rate of the drug. Inclusion of a buffer in the aqueous phase of the emulsion systems was found to retard the release of the drug. The rheological data reveals that there is a correlation between the breakdown of the system and the release of the drug from the system accompanying the addition of sod. Metabisulphite EDTA mixture and buffer solution to the ointment bases.

DOI

10.21608/bfsa.1981.104591

Authors

First Name

H.

Last Name

El-Sourady

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

S.

Last Name

El-Shanawany

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

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Orcid

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Volume

4

Article Issue

1

Related Issue

15861

Issue Date

1981-12-01

Publish Date

1981-12-31

Page Start

82

Page End

98

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 4_Issue 1_Pages 82-98.pdf

PDF . 552.3kB

Link

https://bpsa.journals.ekb.eg/article_104591.html

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https://bpsa.journals.ekb.eg/service?article_code=104591

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

RELEASE AND RHEOLOGICAL CHARACTERISTICS OF CHLORTETRACYCLINE HYDROCHLORIDE OPHTHALMIC OINTMENTS

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Article

Created At

22 Jan 2023