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104590

COLORIMETRIC ASSAY OF HEXAMETHYLENETETRAMINE

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Last updated: 04 Jan 2025

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Abstract

Two photometric procedures are described for the determination of hexamethylenetetramine, free and in pharmaceutical preparation. The two methods are based on color formation by the ammonia released after the hydrolysis of hexamethylenetetramine. In the first method sodium-l,2 naphthoquinone-4-sulphonate reagent was added to the hydrolyzed hexamine sample, after adjustment of the pH of the solution to 9.3, when excess of reagent was eliminated, pink color appeared that was measured at 495 nm (e= 8.6 x l03). Ninhydrin was applied, in the second proposed method, to the hydrolyzed sample of hexamethylenetetramine after adjustment of the solution pH to 6.5. The color produced had its maximum absorbance at 565 nm with high intensity (e= 1.2 x l04). Beer's law was obeyed in the range of concentration of 2-20 mcg of hexamine per ml with standard deviation of ± 0.66 and 2-30 mcg/ml with SD± 0.85 in the case of the first and the second methods respectively. The two methods were applied successfully to the analysis of commercially available hexamethylenetetramine tablets.

DOI

10.21608/bfsa.1981.104590

Authors

First Name

Aly

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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First Name

Nawal

Last Name

El-Rabbat

MiddleName

A.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

Fardous

Last Name

Abdel-Fattah

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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Volume

4

Article Issue

1

Related Issue

15861

Issue Date

1981-12-01

Publish Date

1981-12-31

Page Start

69

Page End

81

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 4_Issue 1_Pages 69-81.pdf

PDF . 470.4kB

Link

https://bpsa.journals.ekb.eg/article_104590.html

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https://bpsa.journals.ekb.eg/service?article_code=104590

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

COLORIMETRIC ASSAY OF HEXAMETHYLENETETRAMINE

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Article

Created At

22 Jan 2023