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103059

EFFECT OF DIRECTLY COMPRESSIBLE VEHICLES ON UNIFORMITY OF CONTENTS OF OXYTETRACYCLINE HYDROCHLORIDE TABLETS

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Last updated: 25 Dec 2024

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Abstract

The effect of microcrystalline cellulose (Avicel), Anhydrous lactose U.S.P., STA-R 1500 and Celutab, on the uniformity of contents of directly compressed oxytetracycline hydrochloride tablets was studied. The vehicles were used singly or in binary mixtures in the ratios 1:1, 3:1 and 1:3. Three different concentrations of vehicles were used plus the control 19.6, 32.6, 42% w/w. It was found that single vehicles produced uniform tablets except those containing high concentration of celutab. On the other hand the uniformity of drug contents of the tablets containing various concentrations of blends of vehicles was found to vary according to the physical properties and the concentrations of the excipients used.

DOI

10.21608/bfsa.1982.103059

Authors

First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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City

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Orcid

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First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

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Orcid

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Volume

5

Article Issue

1

Related Issue

15548

Issue Date

1982-12-01

Receive Date

1981-11-16

Publish Date

1982-12-31

Page Start

199

Page End

209

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 5_Issue 1_Pages 199-209.pdf

PDF . 332.8kB

Link

https://bpsa.journals.ekb.eg/article_103059.html

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https://bpsa.journals.ekb.eg/service?article_code=103059

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15

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF DIRECTLY COMPRESSIBLE VEHICLES ON UNIFORMITY OF CONTENTS OF OXYTETRACYCLINE HYDROCHLORIDE TABLETS

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Article

Created At

22 Jan 2023