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103058

EFFECT OF CERTAIN OPHTHALMIC PREPARATIONS CONTAINING PILOCARPINE HYDROCHLORIDE AND DEXAMETHASONE ON THE INTRAOCULAR PRESSURE OF RABBITS EYE

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Last updated: 25 Dec 2024

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Abstract

The present study deals with the influence of dexamethasone applied locally on the intraocular pressure (I.O.P.) of rabbit and how far this influence may be corrected by the use of the antiglaucoma drug pilocarpine hydrochloride.  It was found that no change in pupillary diameter occurs after instillation of dexamethasone solution. A slight increase in the miotic activity of pilocarpine hydrochloride combined with dexamethasone was observed 15 minutes post-instillation, reaching to maximum within 2-3 hours and then extending to 24 hours. Dexamethasone plus pilocarpine hydrochloride in a w/o emulsion base produced the highest effect after 2-3 hours. The I.O.P. reached to the initial level, 24 hours after application. The ointment seems to form over the corneal surface, an occlusive nonrenewable film, from which pilocarpine hydrochloride is depleted from its aqueous phase. On the other hand dexamethasone lipid solubility permits slow diffusion through the vehicle to replenish the concentration of drug in the film adjacent to the corneal surface. For this reason, the I.O.P did not return to its initial level.

DOI

10.21608/bfsa.1982.103058

Authors

First Name

F.

Last Name

Habib

MiddleName

S.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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Orcid

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First Name

A.

Last Name

Aboutaleb

MiddleName

E.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

M.

Last Name

Attia

MiddleName

A.

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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Orcid

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Volume

5

Article Issue

1

Related Issue

15548

Issue Date

1982-12-01

Receive Date

1981-11-16

Publish Date

1982-12-31

Page Start

185

Page End

198

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 5_Issue 1_Pages 185-198.pdf

PDF . 472.4kB

Link

https://bpsa.journals.ekb.eg/article_103058.html

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https://bpsa.journals.ekb.eg/service?article_code=103058

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF CERTAIN OPHTHALMIC PREPARATIONS CONTAINING PILOCARPINE HYDROCHLORIDE AND DEXAMETHASONE ON THE INTRAOCULAR PRESSURE OF RABBITS EYE

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Article

Created At

22 Jan 2023