Beta
ManageSearchChatDiscover
102101

CNS DEPRESSANT, ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CERTAIN OXANILAMIDE DERIVATIVES

Article

Last updated: 04 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

The present study was designed to evaluate the CNS depressant, analgesic and antiinflammatory activity of six N- {D-threo(-)-1-(p-nitrophenyl)-1,3-dihydroxyisopropyl}-N-4-substituted carbamyol-3-hydroxyoxanilamides. The CNS depressant activity of these compounds was evaluated by measuring their effects on the spontaneous motor activity of mice using the actophotometer technique, while the analgesic activity was evaluated by means of the writhing method. The antiinflammatory response was measured in rats by the trypan blue method. Aspirin was used in these experiments as a reference drug for comparative purposes.  This study revealed that the compounds in question possess certain degree of CNS depressant and analgesic activity comparable but less than that of aspirin. Variable degrees of antiinflammatory activity were observed and the effectiveness of some of these compounds was almost comparable to that of aspirin. The possible correlation between the chemical structure and pharmacological activity was proposed.

DOI

10.21608/bfsa.1983.102101

Authors

First Name

H.

Last Name

El-Bitar

MiddleName

I.

Affiliation

Department of Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

Volume

6

Article Issue

2

Related Issue

15457

Issue Date

1983-12-01

Receive Date

1982-12-29

Publish Date

1983-12-31

Page Start

450

Page End

461

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 6_Issue 2_Pages 450-461.pdf

PDF . 377.5kB

Link

https://bpsa.journals.ekb.eg/article_102101.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=102101

Order

15

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

CNS DEPRESSANT, ANALGESIC AND ANTIINFLAMMATORY ACTIVITY OF CERTAIN OXANILAMIDE DERIVATIVES

Details

Type

Article

Created At

22 Jan 2023