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102094

EFFECT OF SOME ADDITIVES ON THE ANTIMICROBIAL ACTIVITY OF KANAMYCIN AND GENTAMICIN IN OINTMENTS

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Last updated: 04 Jan 2025

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Abstract

Kanamycin and gentamicin ointments were prepared using four different ointment bases, namely oleaginous, absorption, emulsion and water-soluble bases. Glyaerol, Propylene glyaol, polyethylene glycols 200, 400, 600 and 1000, water, alcohol, dimethylformamide, dimethylsulfoxide and polysorbate 80 were separately incorporated at 10% concentration into all the ointments prepared. The effect of all these additives on the antimicrobial activity of gentamicin and kanamycin was investigated. Water-soluble base was found to be the best for preparing kanamycin and gentamicin ointments. Of the additives tested, glycerol, dimethylformamide dimethylsulfoxide and polysorbate 80 proved to have more effect in increasing the activity of kanamycin than the other additives. while for gentamicin, the best effect was with either glycerol, propylene glycol or polyethylene glycol in water soluble base, and with 10% water in oleaginous base.

DOI

10.21608/bfsa.1983.102094

Authors

First Name

A.

Last Name

Kassem

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, El-Azhar University, Nasr City, Cairo, Egypt

Email

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City

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Orcid

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First Name

M.

Last Name

Kassem

MiddleName

A. A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, Egypt

Email

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City

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Orcid

-

First Name

E.

Last Name

Ibrahim

MiddleName

A.

Affiliation

The National Organization for Drug Control and Research, Giza, Egypt

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City

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Orcid

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First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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City

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Orcid

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Volume

6

Article Issue

2

Related Issue

15457

Issue Date

1983-12-01

Receive Date

1982-10-28

Publish Date

1983-12-31

Page Start

351

Page End

360

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 6_Issue 2_Pages 351-360.pdf

PDF . 382.5kB

Link

https://bpsa.journals.ekb.eg/article_102094.html

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https://bpsa.journals.ekb.eg/service?article_code=102094

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SOME ADDITIVES ON THE ANTIMICROBIAL ACTIVITY OF KANAMYCIN AND GENTAMICIN IN OINTMENTS

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Article

Created At

22 Jan 2023