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102090

EFFECT OF SURFACTANTS TREATED BINDER ON THE PHYSICAL PROPERTIES AND BIOAVAILABILITY OF SULFADIAZINE TABLETS

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Last updated: 25 Dec 2024

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Abstract

The effect of untreated gelatin binder along with surfactant treated gelatin on the physical properties of sulfadiazine tablets were studied. Surfactant treated gelatin was found to lower the d.t., and hardness, but increased friability value. Further, the effect of surfactant treated gelatin incorporated in sulfadiazine tablets, on the dissolution rate was studied and was found to be better than untreated ones. Concentration of 2.5% of surfactant proved to be the most convenient in producing tablets with good physical properties and high dissolution rate. The maximum urinary excretion of sulfadiazine and higher physiological bioavailability were observed in case of tablets prepared with surfactant treated gelatin.

DOI

10.21608/bfsa.1983.102090

Authors

First Name

H.

Last Name

El-Sabbagh

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Munsoura University, Mansoura, Egypt

Email

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City

-

Orcid

-

First Name

M.

Last Name

El-Shaboury

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Munsoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Nouh

MiddleName

T.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Munsoura University, Mansoura, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Abd El-Gawad

MiddleName

H.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Munsoura University, Mansoura, Egypt

Email

-

City

-

Orcid

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Volume

6

Article Issue

2

Related Issue

15457

Issue Date

1983-12-01

Receive Date

1982-10-14

Publish Date

1983-12-31

Page Start

295

Page End

309

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 6_Issue 2_Pages 295-309.pdf

PDF . 541.9kB

Link

https://bpsa.journals.ekb.eg/article_102090.html

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https://bpsa.journals.ekb.eg/service?article_code=102090

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF SURFACTANTS TREATED BINDER ON THE PHYSICAL PROPERTIES AND BIOAVAILABILITY OF SULFADIAZINE TABLETS

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Article

Created At

22 Jan 2023