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102084

EFFECT OF BINDER AND ITS CONCENTRATION ON THE PHYSICAL CHARACTERISTICS OF SULFADIAZINE GRANULES AND TABLETS PREPARED BY WET AND FLUIDIZED-BED GRANULATION METHODS

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Last updated: 25 Dec 2024

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Abstract

Sulfadiazine was granulated by the fluidized-bed (Uni-Glatt), as well as by the conventional massing and screening (Wet granulation) methods. The effects of binder concentration and its type on the mechanical properties of granules and their corresponding tablets, as well as on disintegration time and drug content were studied. It was found that the fluidized bed method was an efficient with all tested binders to produce superior granules. However, disintegration time of the corresponding tablets was found to be increased markedly and was greatly affected by the type and the concentration of the binder. Some suggestions to overcome this problem are stated.

DOI

10.21608/bfsa.1983.102084

Authors

First Name

A.

Last Name

Nouh

MiddleName

T. I.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

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Orcid

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Volume

6

Article Issue

2

Related Issue

15457

Issue Date

1983-12-01

Receive Date

1982-08-31

Publish Date

1983-12-31

Page Start

256

Page End

270

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 6_Issue 2_Pages 256-270.pdf

PDF . 532.3kB

Link

https://bpsa.journals.ekb.eg/article_102084.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=102084

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

EFFECT OF BINDER AND ITS CONCENTRATION ON THE PHYSICAL CHARACTERISTICS OF SULFADIAZINE GRANULES AND TABLETS PREPARED BY WET AND FLUIDIZED-BED GRANULATION METHODS

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Article

Created At

22 Jan 2023