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100956

SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE

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Last updated: 25 Dec 2024

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Abstract

A spectrophotometric assay procedure was developed for the quantitative assay of piperazine and phenmetrazine. The method is based on the formation of enamines of these drugs by interaction with acetaldehyde. The resulting enamines interact with chloranil to form the corresponding blue aminovinylquinone which can be quantitated spectrophotometrically at lmax 320 nm for both drugs and at lmax '667 nm and 67C nm for piperazine and phenmetrazine respectively. The Beer-Lambert law adhered to over the 0.5-20 ug/ml range for both drugs at both lmax. The optimum reaction conditions and the effect of variables have been studied. The method has been applied successfully to the analysis of commercially available piperazine tablets, ampoules and effervescent granules.

DOI

10.21608/bfsa.1983.100956

Authors

First Name

S.

Last Name

El-Shabouri

MiddleName

R.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

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Orcid

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First Name

M.

Last Name

Amer

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

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City

-

Orcid

-

First Name

A.

Last Name

Taha

MiddleName

M.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

P.

Last Name

Khashaba

MiddleName

Y.

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

-

Volume

6

Article Issue

1

Related Issue

15296

Issue Date

1983-06-01

Receive Date

1982-08-28

Publish Date

1983-06-30

Page Start

226

Page End

242

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 6_Issue 1_Pages 226-242.pdf

PDF . 476.7kB

Link

https://bpsa.journals.ekb.eg/article_100956.html

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https://bpsa.journals.ekb.eg/service?article_code=100956

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

SPECTROPHOTOMETRIC DETERMINATION OF PIPERIDINE, PIPERAZINE AND PHENMETRAZINE

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Article

Created At

22 Jan 2023