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93599

PERFORMANCE OF CURCUMIN IN NANOSIZED CARRIERS NIOSOMES AND ETHOSOMES AS POTENTIAL ANTI-INFLAMMATORY DELIVERY SYSTEM FOR TOPICAL APPLICATION

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Last updated: 04 Jan 2025

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Abstract

Curcumin (CUR) is one of the most commonly used herbal product; it shows effective anti-inflammatory and anti-oxidant effects. However, poor aqueous solubility and low permeability are the major challenges in therapeutic application of curcumin. One class of vesicular nanocarriers called “Niosome and ethosome" which have proved to possess distinct advantages were used to encapsulate curcumin and evaluated for their morphology, particle size, zeta potential, entrapment efficiency (EE%) and drug release. They were incorporated into hydroxy propyl methyl cellulose (HPMC15000) gel then, evaluated on the rat skin via inhibition of carrageenan induced rat paw edema. The results showed that the particle size of curcumin loaded niosomes and ethosomes were ranged (317.5±1.91 to 558.3±8.587 nm) and (182.1±5.3 to 354.5±30.03 nm), respectively. Skin permeation studies demonstrated that CUR permeability coefficient through rat kin for gel formulations of loaded vesicles was ~ four times higher as compared to free CUR. The in-vivo anti-inflammatory studies proved that gel formulations of CUR vesicles possessed higher significant inhibition of carrageenan induced rat paw edema when compared to pure curcumin. Accordingly, the results revealed that, curcumin loaded nanovesicels held great potential approaches as anti-inflammatory in topical application.

DOI

10.21608/bfsa.2020.93599

Authors

First Name

Mona

Last Name

El-Mahdy

MiddleName

M.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University. Assiut 71526, Egypt

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Orcid

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First Name

Abeer

Last Name

Hassan

MiddleName

S.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena 83523, Egypt

Email

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City

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Orcid

-

First Name

Mahmoud

Last Name

El-Badry

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University. Assiut 71526, Egypt & Assiut International Center of Nanomedicine, Al-Rajhy Liver Hospital, Assiut University, Assiut 71515, Egypt

Email

elbadry@aun.edu.eg

City

-

Orcid

-

First Name

Gamal El-Din

Last Name

El-Gindy

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University. Assiut 71526, Egypt

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Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-03-29

Publish Date

2020-06-30

Page Start

105

Page End

122

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 105-122.pdf

PDF . 2.4MB

Link

https://bpsa.journals.ekb.eg/article_93599.html

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https://bpsa.journals.ekb.eg/service?article_code=93599

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

PERFORMANCE OF CURCUMIN IN NANOSIZED CARRIERS NIOSOMES AND ETHOSOMES AS POTENTIAL ANTI-INFLAMMATORY DELIVERY SYSTEM FOR TOPICAL APPLICATION

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Article

Created At

22 Jan 2023