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93596

HOW DOES QUINOLONES ANTIBOTIC RESISTANCE DEVELOP?

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Last updated: 04 Jan 2025

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Abstract

The quinolone antibiotics arose in the early 1960s, with the first example having a narrow spectrum of activity with unfavourable pharmacokinetics. Over time, the development of new quinolone antibiotics has led to improved equivalents with an expanded spectrum and high efficacy. Nowadays, quinolones are broad-spectrum antibiotics that are active against both Gram-positive and Gram-negative bacteria, as well as mycobacteria, and anaerobes. They exert their actions by inhibiting bacterial nucleic acid synthesis through disrupting the enzymes topoisomerase IV and DNA gyrase, and by causing damage of bacterial chromosomes. Acquired bacterial resistance to quinolones rises due to the abuse of these drugs. Mechanisms contributing to quinolone resistance are mediated by chromosomal mutations and/or plasmid gene uptake that modify topoisomerase targets, modify the quinolone, and/or reduce drug accumulation by either decreased uptake or increased efflux. This review describes the history of development of this class of antibiotics, different generations, mechanism of action, along with the resistance mechanisms which reduce the quinolones' activities against different microorganisms.

DOI

10.21608/bfsa.2020.93596

Authors

First Name

Marwa

Last Name

Sabet

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Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt & Ministry of Health and Population, Assiut, Egypt

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First Name

Enas

Last Name

Daef

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Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

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First Name

Doaa

Last Name

Ghaith

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Department of Clinical and Chemical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt

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First Name

Michael

Last Name

Agban

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-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

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First Name

Sherine

Last Name

Aly

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A.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt

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Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-03-05

Publish Date

2020-06-30

Page Start

95

Page End

104

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 95-104.pdf

PDF . 7.1MB

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https://bpsa.journals.ekb.eg/article_93596.html

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https://bpsa.journals.ekb.eg/service?article_code=93596

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Original Article

Type Code

1,096

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Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

HOW DOES QUINOLONES ANTIBOTIC RESISTANCE DEVELOP?

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Article

Created At

22 Jan 2023