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93593

KETOROLAC TROMETHAMINE LOADED NANOPARTICLES FOR OCULAR DELIVERY: FORMULATION, IN-VITRO AND EX-VIVO EVALUATION

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Last updated: 25 Dec 2024

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Abstract

The objective of the current study was preparation of ketorolac tromethamine (KT) loaded nanoparticles (NPs) based on two polymers (Eudragit RL 100 and Gelatin) for ocular applications providing a controlled drug release to improve KT bioavailability. Nanoprecipitation technique was used to prepare eudragit RL 100 NPs while gelatin NPs were prepared using two-step desolvation technique. The formulations were evaluated in terms of particle size, zeta potential, polydispersibity index (PDI) and physicochemical characterizations (DSC, FTIR, X-ray diffraction). Drug entrapment, in-vitro release, ex-vivo permeation, histological examination and stability at different conditions were also examined. The optimized parameters have been determined and were suitable for possible ocular application. NPs showed sustained drug release in-vitro and higher permeation as compared to that of Acular® solution. These preliminary results indicated that KT loaded NPs are effective in sustaining drug release and could be used for improving ocular delivery of KT.

DOI

10.21608/bfsa.2020.93593

Authors

First Name

Raafat

Last Name

Osman

MiddleName

Elsayed

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

raafat200027@yahoo.com

City

-

Orcid

-

First Name

Gihan

Last Name

Fetih

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

Email

-

City

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Orcid

-

First Name

Fawzia

Last Name

Habib

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt

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-

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-

Orcid

-

Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-02-23

Publish Date

2020-06-30

Page Start

79

Page End

94

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 79-94.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_93593.html

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https://bpsa.journals.ekb.eg/service?article_code=93593

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

KETOROLAC TROMETHAMINE LOADED NANOPARTICLES FOR OCULAR DELIVERY: FORMULATION, IN-VITRO AND EX-VIVO EVALUATION

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Article

Created At

22 Jan 2023