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93587

THE ROLE OF VISFATIN AND CYTOGLOBIN IN OBESE DIABETIC RATS: THE MODULATORY EFFECTS OF RASPBERRY KETONE

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Last updated: 04 Jan 2025

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Abstract

Introduction: Clinical and epidemiological studies suggest that patients who are overweight or obese are more at risk in developing glucose intolerance (G/I) and insulin resistance (I/R) leading to type 2 diabetes (T2DM) and cardiovascular disease.
Aim of work: Assess the dynamic contribution of visfatin in the development of obesity and/or diabetes and demonstrate their possible molecular mechanism(s) from side and from another side, modulate role of Raspberry ketone (RK) as weight management supplement and illustrate their possible molecular mechanism(s).
Materials and Methods: Eighty adult rats were divided into eight groups (10 rats for each group, G); G1: Normal Control Group (Normal diet); G2: Diabetic Control Group (received streptozotocin 35 mg/kg); G3: Obese Control Group (received high fat diet, HFD); G4: Obese Diabetic Control Group, G5: Raspberry ketone Control Group (received 500 mg/kg), G6: Diabetic rats treated with Raspberry ketone; G7: Obese rats treated with Raspberry ketone and G8: Obese Diabetic rats treated with Raspberry ketone to assess the study's aims, their effect was determined on body weight, OGTT, glucose homeostasis (glucose, insulin, HOMA-IR), oxidative stress markers, cytoglobin, visfatin and liver histopathology.
Results: RK caused weight loss, corrected the disturbed glucose and insulin homeostasis, Furthermore, RK increased hepatic content of glutathione (GSH), while decreased hepatic content of malonaldialdehyde (MDA). RK also up regulated hepatic protein expression of cytoglobin, while down regulated hepatic mRNA expression of visfatin.
Conclusion: This study assessed the involvement of visfatin and cytoglobin in obese diabetic rats and modulated the role of RK through the efficient rebalance of glucose homeostasis, I/R, the redox status and liver histopathology.

DOI

10.21608/bfsa.2020.93587

Authors

First Name

Hussein

Last Name

Hussein

MiddleName

T.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

dr_h_t_h@yahoo.com

City

-

Orcid

-

First Name

Hosny

Last Name

Hassan

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Medicine, Assuit University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Hafez

Last Name

Madkor

MiddleName

H.R.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

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-

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdel-Ghany

MiddleName

A.

Affiliation

Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

Email

-

City

-

Orcid

-

First Name

Kawkab

Last Name

Ahmed

MiddleName

A.

Affiliation

Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

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-

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-

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Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-02-20

Publish Date

2020-06-30

Page Start

53

Page End

72

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 53-72.pdf

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https://bpsa.journals.ekb.eg/article_93587.html

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https://bpsa.journals.ekb.eg/service?article_code=93587

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5

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Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE ROLE OF VISFATIN AND CYTOGLOBIN IN OBESE DIABETIC RATS: THE MODULATORY EFFECTS OF RASPBERRY KETONE

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Article

Created At

22 Jan 2023