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93573

THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY

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Last updated: 04 Jan 2025

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Abstract

Therapeutic nucleic acids must be formulated in delivery systems that permit them to be efficiently targeted to specific tissues within the body and to overcome the endosomal barrier to deliver these molecules to their intracellular target sites. GALA is a synthetic amphipathic 30 amino acids peptide that performs both functions. It has the ability to target the lung endothelium and induce membrane fusion, which facilitates endosomal escape of therapeutic nucleic acids. In this review, we introduce the GALA peptide and discuss its multiple roles in drug and gene delivery. We first describe the peptide and its ability to induce membrane fusion and pore-formation. We next focus on applications of this peptide in gene delivery in-vitro and in-vivo. We also discuss the synergistic combination between GALA and oligoargnine peptides and their applicability to active tumor targeting. The GALA peptide introduced in this review has great promise as an efficient tool for gene delivery.

DOI

10.21608/bfsa.2020.93573

Authors

First Name

Ikramy

Last Name

Khalil

MiddleName

A.

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Email

ikramy@aun.edu.eg

City

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Orcid

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First Name

Hideyoshi

Last Name

Harashima

MiddleName

-

Affiliation

Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan

Email

harasima@pharm.hokudai.ac.jp

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Orcid

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Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-02-04

Publish Date

2020-06-30

Page Start

39

Page End

51

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 39-51.pdf

PDF . 763.5kB

Link

https://bpsa.journals.ekb.eg/article_93573.html

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https://bpsa.journals.ekb.eg/service?article_code=93573

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Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

THE GALA PEPTIDE: MULTIPLE ROLES IN DRUG AND GENE DELIVERY

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Article

Created At

22 Jan 2023