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93530

INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE

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Last updated: 25 Dec 2024

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Abstract

The objectives of the current study were to investigate the influence of different types and concentration of polymers on release of ciprofloxacin HCl as well as to formulate an extended release tablets of ciprofloxacin hydrochloride by direct compression method. Twelve formulations (F1–F12) were manually designed using different proportions (10–30%) of Hydroxypropyl methylcellulose (HPMC), Ethylcellulose (EC) and Kollidon SR polymers. Avicel PH101, talc and magnesium stearate were used in a constant quantity of 2% in all the formulations. Multiple point dissolution was carried out in different media. Dissolution profiles indicated that formulations F1, F4, F8 and F11, extended the drug release up to 12 hrs, while, other formulations failed to retard the drug release up to desired period. DDSolver software was used to analyze the dissolution profile data for drug release kinetics such as first order, Zero-order, Korsmeyer–Peppas and Higuchi models. Drug polymers compatibility was assessed using Fourier Transformed Infrared (FTIR) spectroscopy. Selected formulations were placed in the stability chamber at accelerated temperature (40±2°C and RH 75±5%) for six months and re-evaluated after 3 and 6 months as per ICH guidelines. The present study accomplished that ethylcellulose alone or in combination with HPMC was found to be an excellent rate controlling agent for ciprofloxacin and may be used successfully to develop extended release tablet formulations.

DOI

10.21608/bfsa.2020.93530

Authors

First Name

Rida

Last Name

Khalid

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

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City

-

Orcid

-

First Name

Muhammad

Last Name

Nasiri

MiddleName

Iqbal

Affiliation

Department of Pharmaceutics, Hamdard Institute of Pharmaceutical Sciences, Hamdard University, Islamabad, Pakistan

Email

-

City

-

Orcid

-

First Name

Humera

Last Name

Sarwar

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

-

City

-

Orcid

-

First Name

Riffat

Last Name

Yasmin

MiddleName

-

Affiliation

Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

Email

-

City

-

Orcid

-

First Name

Kamran

Last Name

Zaheer

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

kamranzaheer63@hotmail.com

City

-

Orcid

-

First Name

Sohail

Last Name

Anwer

MiddleName

-

Affiliation

Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Email

-

City

-

Orcid

-

First Name

Anab

Last Name

Fatima

MiddleName

-

Affiliation

Department of Pharmaceutics, Dow College of Pharmacy, Dow University of Health Sciences, Karachi, Pakistan

Email

-

City

-

Orcid

-

Volume

43

Article Issue

1

Related Issue

14112

Issue Date

2020-06-01

Receive Date

2020-01-15

Publish Date

2020-06-30

Page Start

11

Page End

25

Print ISSN

1110-0052

Online ISSN

3009-7703

Article File

BFSA_Volume 43_Issue 1_Pages 11-25.pdf

PDF . 1.4MB

Link

https://bpsa.journals.ekb.eg/article_93530.html

Detail API

https://bpsa.journals.ekb.eg/service?article_code=93530

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2

Type

Original Article

Type Code

1,096

Publication Type

Journal

Publication Title

Bulletin of Pharmaceutical Sciences Assiut University

Publication Link

https://bpsa.journals.ekb.eg/

MainTitle

INFLUENCE OF CELLULOSE AND ACETATE-BASED POLYMERS ON THE RELEASE OF CIPROFLOXACIN HCL FROM EXTENDED RELEASE MATRIX TABLETS PREPARED BY DIRECT COMPRESSION TECHNIQUE

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Article

Created At

22 Jan 2023